Farmacologia e Toxicologia

Veterinary Pharmacology and Therapeutics, 10th Edition

De: Jim E. Riviere (Editor), Mark G. Papich (Editor)
ISBN: 9781118855829|
2018, Wiley
Capa dura
Páginas: 1552

  • Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species.

    • Provides current, detailed information on using drug therapies in all major domestic animal species
    • Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine
    • Includes extensive tables of pharmacokinetic data, products available, and dosage regimens
    • Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology
    • Includes access to a companion website with the figures from the book in PowerPoint
  • Contributors xiii

    Preface xix

    About the Companion Website xxi

    Section ÆÌ Principles of Pharmacology 1

    Veterinary Pharmacology: An Introduction to the Discipline 3
    Jim E. Riviere and Mark G. Papich

    Absorption, Distribution, Metabolism, and Elimination 8
    Jim E. Riviere

    Pharmacokinetics 41
    Jim E. Riviere

    Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65
    Pierre-Louis Toutain

    Principles of Pharmaceutics and Veterinary Dosage Forms 87
    Raafat M. Fahmy and Marilyn N. Martinez

    Section f Drugs Acting on the Autonomic Nervous System 111

    Introduction to the Autonomic Nervous Systemand Autonomic Pharmacology 113
    Joshua A. Rowe, RoseM.McMurphy, Barbara J. Lutjemeier, andMichael J. Kenney

    Adrenergic Receptor Agonists and Antagonists 131
    Rose M.McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney

    Cholinergic Pharmacology: Autonomic Drugs 151
    RoseM.McMurphy, Elizabeth G. Davis, Amy J. Rankin,Marjory A. Artzer, Barbara J. Lutjemeier, andMichael J. Kenney

    Section g Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165

    Introduction to Drugs Acting on the Central Nervous Systemand Principles of Anesthesiology 167
    Peter J. Pascoe and Eugene P. Steffey

    Neuromuscular Blocking Agents 194
    Diane E.Mason and Christopher L. Norkus

    Inhalation Anesthetics 216
    Robert J. Brosnan and Eugene P. Steffey

    Injectable Anesthetic Agents 247
    Lysa P. Posner

    Opioid Analgesic Drugs 281
    Butch KuKanich andMark G. Papich

    Sedatives and Tranquilizers 324
    Lysa P. Posner

    Local Anesthetics 369
    Thomas W. Vickroy

    Euthanizing Agents 387
    Anna Hampton

    Anticonvulsant Drugs 395
    Mark G. Papich

    Drugs Affecting Animal Behavior 416
    Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich

    Section h Autacoids and Antiinflammatory Drugs 449

    Histamine, Serotonin, and their Antagonists 451
    Wolfgang B¨aumer

    Analgesic, Antiinflammatory, Antipyretic Drugs 467
    Peter Lees

    Section i Drugs Acting on the Cardiovascular System 501

    Digitalis, Positive Inotropes, and Vasodilators 503
    Clarke E. Atkins and Marisa K. Ames

    Antiarrhythmic Agents 537
    Kathryn M. Meurs and Jim E. Riviere

    Section j Drugs Affecting Renal Function and Fluid–Electrolyte Balance 553

    Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555
    Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar

    Diuretics and Renal Pharmacology 593
    Butch Kukanich and Deborah T. Kochevar

    Section k Drugs Acting on Blood and Blood Elements 623

    Anticoagulant, Antiplatelet, and Hemostatic Drugs 625
    Mark G. Papich

    Section l Endocrine Pharmacology 647

    Hypothalamic and Pituitary Hormones 649
    Srujana Rayalam,Margarethe Hoenig, and Duncan C. Ferguson

    Hormones Affecting Reproduction 674
    Wolfgang B¨aumer, C. Scott Bailey, and John Gadsby

    Thyroid Hormone and Antithyroid Drugs 691
    Duncan C. Ferguson

    Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729
    Duncan C. Ferguson and Margarethe Hoenig

    Drugs Influencing Glucose Metabolism 763
    Margarethe Hoenig

    Chemotherapy of Microbial Diseases 779

    Antiseptics and Disinfectants 781
    Megan E. Jacob

    Sulfonamides and Potentiated Sulfonamides 796
    Mark G. Papich

    ?-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 826
    Mark G. Papich

    Tetracycline Antibiotics 858
    Mark G. Papich and Jim E. Riviere

    Aminoglycoside Antibiotics 877
    Mark G. Papich and Jim E. Riviere

    Chloramphenicol and Derivatives, Macrolides, Lincosamides, andMiscellaneous Antimicrobials 903
    Mark G. Papich

    Fluoroquinolone Antimicrobial Drugs 953
    Mark G. Papich

    Antifungal and Antiviral Drugs 988
    Jennifer L. Davis and LaraMaxwell

    Section ÆÌe Chemotherapy of Parasitic Diseases 1033

    Antinematodal Drugs 1035
    Carlos E. Lanusse, JuanM. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez

    Anticestodal and Antitrematodal Drugs 1081
    Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel

    Macrocyclic Lactones: Endectocide Compounds 1102
    Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz

    Antiprotozoan Drugs 1128
    Jennifer L. Davis and Jody L. Gookin

    Ectoparasiticides 1166
    Ronald E. Baynes

    Section ÆÌÆÌ Specialty Areas of Pharmacology 1189

    Chemotherapy of Neoplastic Diseases 1191
    Luke A.Wittenburg and Daniel L. Gustafson

    Immunosuppressive Drugs 1226
    Mark G. Papich

    Drugs for Treating Gastrointestinal Diseases 1245
    Mark G. Papich

    Dermatopharmacology: Drugs Acting Locally on the Skin 1278
    Jim E. Riviere and Rosanna Marsella

    Drugs that Affect the Respiratory System 1302
    Mark G. Papich

    Ophthalmic Pharmacology 1321
    Alison Clode

    Pharmacogenomics 1332
    Katrina L.Mealey

    Considerations for TreatingMinor Food-Producing Animals with Veterinary Pharmaceuticals 1345
    Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring

    Unique Considerations Pertaining to the Use of Drugs in Food Animals 1358
    Michael D. Apley

    Pharmacology in Aquatic Animals 1373
    Ron A.Miller

    Zoological Pharmacology 1395
    Robert P. Hunter

    Section ÆÌf Regulatory and Other Considerations 1405

    The Regulation of Animal Drugs 1407
    Steven D. Vaughn andMarilyn N. Martinez

    Veterinary Pharmacy 1427
    Gigi Davidson andMark G. Papich

    Medication Control Programs in Performance Animals 1439
    Cynthia A. Cole

    Pharmacovigilance 1448
    John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer

    Dosage Forms And Veterinary Feed Directives 1459
    Geof Smith and Jim E. Riviere

    Evidence-Based Pharmacotherapy 1465
    Ronette Gehring

    Chemical Residues In Tissues Of Food Animals 1469
    Jim E. Riviere

    Index 1481Table of contents

    Contributors xiii

    Preface xix

    About the Companion Website xxi

    Section ÆÌ Principles of Pharmacology 1

    Veterinary Pharmacology: An Introduction to the Discipline 3
    Jim E. Riviere and Mark G. Papich

    Absorption, Distribution, Metabolism, and Elimination 8
    Jim E. Riviere

    Pharmacokinetics 41
    Jim E. Riviere

    Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65
    Pierre-Louis Toutain

    Principles of Pharmaceutics and Veterinary Dosage Forms 87
    Raafat M. Fahmy and Marilyn N. Martinez

    Section f Drugs Acting on the Autonomic Nervous System 111

    Introduction to the Autonomic Nervous Systemand Autonomic Pharmacology 113
    Joshua A. Rowe, RoseM.McMurphy, Barbara J. Lutjemeier, andMichael J. Kenney

    Adrenergic Receptor Agonists and Antagonists 131
    Rose M.McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney

    Cholinergic Pharmacology: Autonomic Drugs 151
    RoseM.McMurphy, Elizabeth G. Davis, Amy J. Rankin,Marjory A. Artzer, Barbara J. Lutjemeier, andMichael J. Kenney

    Section g Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165

    Introduction to Drugs Acting on the Central Nervous Systemand Principles of Anesthesiology 167
    Peter J. Pascoe and Eugene P. Steffey

    Neuromuscular Blocking Agents 194
    Diane E.Mason and Christopher L. Norkus

    Inhalation Anesthetics 216
    Robert J. Brosnan and Eugene P. Steffey

    Injectable Anesthetic Agents 247
    Lysa P. Posner

    Opioid Analgesic Drugs 281
    Butch KuKanich andMark G. Papich

    Sedatives and Tranquilizers 324
    Lysa P. Posner

    Local Anesthetics 369
    Thomas W. Vickroy

    Euthanizing Agents 387
    Anna Hampton

    Anticonvulsant Drugs 395
    Mark G. Papich

    Drugs Affecting Animal Behavior 416
    Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich

    Section h Autacoids and Antiinflammatory Drugs 449

    Histamine, Serotonin, and their Antagonists 451
    Wolfgang B¨aumer

    Analgesic, Antiinflammatory, Antipyretic Drugs 467
    Peter Lees

    Section i Drugs Acting on the Cardiovascular System 501

    Digitalis, Positive Inotropes, and Vasodilators 503
    Clarke E. Atkins and Marisa K. Ames

    Antiarrhythmic Agents 537
    Kathryn M. Meurs and Jim E. Riviere

    Section j Drugs Affecting Renal Function and Fluid–Electrolyte Balance 553

    Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555
    Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar

    Diuretics and Renal Pharmacology 593
    Butch Kukanich and Deborah T. Kochevar

    Section k Drugs Acting on Blood and Blood Elements 623

    Anticoagulant, Antiplatelet, and Hemostatic Drugs 625
    Mark G. Papich

    Section l Endocrine Pharmacology 647

    Hypothalamic and Pituitary Hormones 649
    Srujana Rayalam,Margarethe Hoenig, and Duncan C. Ferguson

    Hormones Affecting Reproduction 674
    Wolfgang B¨aumer, C. Scott Bailey, and John Gadsby

    Thyroid Hormone and Antithyroid Drugs 691
    Duncan C. Ferguson

    Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729
    Duncan C. Ferguson and Margarethe Hoenig

    Drugs Influencing Glucose Metabolism 763
    Margarethe Hoenig

    Chemotherapy of Microbial Diseases 779

    Antiseptics and Disinfectants 781
    Megan E. Jacob

    Sulfonamides and Potentiated Sulfonamides 796
    Mark G. Papich

    ?-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 826
    Mark G. Papich

    Tetracycline Antibiotics 858
    Mark G. Papich and Jim E. Riviere

    Aminoglycoside Antibiotics 877
    Mark G. Papich and Jim E. Riviere

    Chloramphenicol and Derivatives, Macrolides, Lincosamides, andMiscellaneous Antimicrobials 903
    Mark G. Papich

    Fluoroquinolone Antimicrobial Drugs 953
    Mark G. Papich

    Antifungal and Antiviral Drugs 988
    Jennifer L. Davis and LaraMaxwell

    Section ÆÌe Chemotherapy of Parasitic Diseases 1033

    Antinematodal Drugs 1035
    Carlos E. Lanusse, JuanM. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez

    Anticestodal and Antitrematodal Drugs 1081
    Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel

    Macrocyclic Lactones: Endectocide Compounds 1102
    Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz

    Antiprotozoan Drugs 1128
    Jennifer L. Davis and Jody L. Gookin

    Ectoparasiticides 1166
    Ronald E. Baynes

    Section ÆÌÆÌ Specialty Areas of Pharmacology 1189

    Chemotherapy of Neoplastic Diseases 1191
    Luke A.Wittenburg and Daniel L. Gustafson

    Immunosuppressive Drugs 1226
    Mark G. Papich

    Drugs for Treating Gastrointestinal Diseases 1245
    Mark G. Papich

    Dermatopharmacology: Drugs Acting Locally on the Skin 1278
    Jim E. Riviere and Rosanna Marsella

    Drugs that Affect the Respiratory System 1302
    Mark G. Papich

    Ophthalmic Pharmacology 1321
    Alison Clode

    Pharmacogenomics 1332
    Katrina L.Mealey

    Considerations for TreatingMinor Food-Producing Animals with Veterinary Pharmaceuticals 1345
    Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring

    Unique Considerations Pertaining to the Use of Drugs in Food Animals 1358
    Michael D. Apley

    Pharmacology in Aquatic Animals 1373
    Ron A.Miller

    Zoological Pharmacology 1395
    Robert P. Hunter

    Section ÆÌf Regulatory and Other Considerations 1405

    The Regulation of Animal Drugs 1407
    Steven D. Vaughn andMarilyn N. Martinez

    Veterinary Pharmacy 1427
    Gigi Davidson andMark G. Papich

    Medication Control Programs in Performance Animals 1439
    Cynthia A. Cole

    Pharmacovigilance 1448
    John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer

    Dosage Forms And Veterinary Feed Directives 1459
    Geof Smith and Jim E. Riviere

    Evidence-Based Pharmacotherapy 1465
    Ronette Gehring

    Chemical Residues In Tissues Of Food Animals 1469
    Jim E. Riviere

    Index 1481

  • Jim E. Riviere, DVM, PhD, DSc (hon), ATS, is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA.

    Mark G. Papich, DVM, MS, Diplomate ACVCP, has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA.

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