• The global spread of antimicrobial-resistant pathogenic bacteria is a continuing challenge to the health care of humans and domesticated animals. With no new agents on the horizon, it is imperative to use antimicrobial agents wisely to preserve their future efficacy.

    Led by Editors Stefan Schwarz, Lina Maria Cavaco, and Jianzhong Shen with Frank Møller Aarestrup, an international team of experts in antimicrobial resistance of livestock and companion animals has created this valuable reference for veterinary students and practitioners as well as researchers and decision makers interested in understanding and preventing antimicrobial resistance.

    REVIEWS

    In this era of “superbugs” and rising antimicrobial resistance, Antimicrobial Resistance in Bacteria from Livestock and Companion Animals is a valuable resource to better understand the contribution of animal-derived pathogens to this growing public health crisis. The use of antimicrobial drugs in animal populations is not without controversy; the underlying concern, of course, is that antimicrobial use in animals results in illness and death in humans. This text does not seek to specifically condemn or exonerate. Instead, it provides a comprehensive account of a very complicated topic, delving into the nuances needed to understand the what, where, when, and why of antimicrobial resistance in companion animals and livestock.

    The text begins with a historical overview of the discovery of antimicrobial drugs and a detailed characterization of the indications for and regulation of their use in veterinary medicine. Salient technical issues are discussed, including antimicrobial susceptibility testing in veterinary pathogens, diagnostic methods for detecting antimicrobial resistance, and licensing of antimicrobial drugs. Overviews of the mechanisms of resistance to antimicrobial agents, including antibiotics, metals, and biocides, provide context to the main substance of the text: an exhaustive report of current antimicrobial resistance in a wide range of pathogens of veterinary and medical importance. The text closes with a look into the future of mitigating antimicrobial resistance in veterinary and production settings through monitoring, surveillance, and antimicrobial stewardship.

    Antimicrobial Resistance in Bacteria from Livestock and Companion Animals presents a wealth of information and is a critical resource for anyone who studies, treats, or is affected by antimicrobial resistance in domesticated animals or the food products that come from them. Contributing authors are globally renowned experts in the field who have composed thoughtful and insightful accounts that generally walk the line between technically thorough and accessible to a broad audience. Whether one is interested in a specific pathogen or in policy to mitigate antimicrobial resistance, this text offers a comprehensive review of the increasingly urgent topic that is antimicrobial resistance in animal-derived pathogens.

    Laurel Redding, University of Pennsylvania, Kennett Square, Pennsylvania, USA

    Original Publication Date: November 06, 2019

  • Contributors

    Foreword

    Preface

    About the Authors

    1. History and current use of antimicrobial drugs in veterinary medicine
    John F. Prescott

    2. Antimicrobial Susceptibility Testing of Bacteria of Veterinary Origin; Breakpoints
    Jeffrey L. Watts, Michael T. Sweeney, Brian V. Lubbers

    3. New and Molecular Methods for the Detection of Antimicrobial Resistance (including MALDI-TOF, NGS, DNA array)
    Muna F. Anjum, Ea Zankari, and Henrik Hasman

    4. Mechanisms and Transmission of Bacterial Resistance to Antimicrobial Agents
    Engeline van Duijkeren, Anne-Kathrin Schink, Marilyn C. Roberts, Yang Wang, and Stefan Schwarz

    5. Resistance to Metals Used in Agricultural Production
    Christopher Rensing, Arshnee Moodley, Lina M. Cavaco, and Sylvia Franke McDevitt

    6. Resistance to Biocides in Bacteria
    Jean-Yves Maillard

    7. Antimicrobial Resistance among Staphylococci of Animal Origin
    Stefan Schwarz, Andrea T. Feßler, Igor Loncaric, Congming Wu, Kristina Kadlec, Yang Wang, and Jianzhong Shen

    8. Antimicrobial Resistance in Streptococcus spp.
    Marisa Haenni, Agnese Lupo, Jean-Yves Madec

    9. Antimicrobial Resistance in Enterococcus spp.
    Carmen Torres, Carla Andrea Alonso, Laura Ruiz-Ripa, Ricardo León-Sampedro, Rosa del Campo, and Teresa Coque

    10. Antimicrobial Resistance in Rhodococcus equi
    Steeve Giguère, Londa J. Berghaus, and Jennifer Willingham-Lane

    11. Antimicrobial Resistance in Listeria spp.
    Laura Luque-Sastre, Cristina Arroyo, Edward M. Fox, Barry J. McMahon, Li Bai, Fengqin Li, and Séamus Fanning

    12. Antimicrobial Resistance in Nontyphoidal Salmonella
    Patrick F. McDermott, Shaohua Zhao, and Heather Tate

    13. Antimicrobial Resistance in Escherichia coli
    Laurent Poirel, Jean-Yves Madec, Agnese Lupo, Anne-Kathrin Schink, Nicolas Kieffer, Patrice Nordmann, Stefan Schwarz

    14. Antimicrobial Resistance in Campylobacter spp.
    Zhangqi Shen, Yang Wang, Qijing Zhang, and Jianzhong Shen

    15. Antimicrobial Resistance in Pasteurellaceae of Veterinary Origin
    Geovana B. Michael, Janine Bossé, and Stefan Schwarz

    16. Antimicrobial Resistance in Bordetella bronchiseptica
    Kristina Kadlec, and Stefan Schwarz

    17. Antimicrobial Resistance in Pseudomonas spp. and Acinetobacter spp.
    Agnese Lupo, Marisa Haenni, and Jean-Yves Madec

    18. Antimicrobial Resistance in Corynebacterium spp., Arcanobacterium spp., and Trueperella pyogenes
    Andrea T. Feßler, Stefan Schwarz

    19. Antimicrobial Resistance in Stenotrophomonas spp.
    Yang Wang, Tao He, Zhanggi Shen, and Congming Wu

    20. Antimicrobial Resistance in Mycoplasma spp.
    Anne V. Gautier-Bouchardon

    21. Antimicrobial Resistance in Clostridium spp., Brachyspira spp., and other Anaerobes
    Marie Archambault, and Joseph Rubin

    22. Antimicrobial Resistance in Leptospira, Brucella and Other Rarely Investigated Veterinary and Zoonotic Pathogens
    Darren J. Trott, Sam Abraham, and Ben Adler

    23. Antimicrobial Resistance in Chlamydiales, Rickettsia, Coxiella, and Other Intracellular Pathogens
    Daisy Vanrompay, Thi Loan Anh Nguyen, Sally J. Cutler, and Patrick Butaye

    24. Antimicrobial Drug Resistance in Fish Pathogens
    Ron A. Miller and Heather Harbottle

    25. Antimicrobial Resistance in One-Health perspective
    Scott A. McEwen and Peter J. Colignon

    26. Licensing and Approval of Antimicrobial Agents for Use in Animals
    Constança Pomba, Boudewijn Catry, Jordi Torren Edo, and Helen Jukes

    27. Monitoring Antimicrobial Drug Usage in Animals: Methods and Applications
    Nicole Werner, Scott A. McEwen, and Lothar Kreienbrock

    28. The Present and Future Surveillance of Antimicrobial Resistance in Animals: Principles and Practices
    Shabbir Simjee, Patrick F. McDermott, Darren J. Trott, Chuanchuen Rungtip

    29. Source Attribution Models and Risk Assessment
    Sara M. Pires, Ana SofiaDuarte, and Tine Hald

    30. Optimization of Treatment to Minimize Resistance Selection
    Luca Guardabassi, Mike Apley, John Elmerdahl Olsen, Peirre-Louis Toutain, and Scott Weese

    31. Antimicrobial Stewardship in Veterinary Medicine
    David H. Lloyd and Stephen W. Page

    Index

  • Stefan Schwarz (Editor)

    Lina Maria Cavaco (Editor)

    Jianzhong Shen (Editor)

Veterinary Clinics of North America
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