Small Animal Imaging Basics and Practical Guide

De: Fabian Kiessling, Bernd J.Pichler, Peter Hauff
ISBN: 9783319422008
2017, Springer
Capa dura
Páginas: 856

- Provides invaluable practical guidance on the use of small animal imaging in preclinical research
- Offers detailed coverage of the available imaging modalities, including newly emerging ones, with the aid of numerous illustrations
- Will assist in the installation of a small animal unit, study planning, animal handling, and cost-effective imaging
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
- Noninvasive Imaging for Supporting Basic Research
Pages 3-32

Zanzonico, Pat, PhD, DABR
- Non-invasive Imaging in the Pharmaceutical Industry
Pages 33-46

Emmas, Sally-Ann (et al.)
- Designing a Small Animal Imaging Center
Pages 47-67

Stout, David, PhD
- Noninvasive Small Rodent Imaging: Significance for the 3R Principles
Pages 69-87

Beckmann, Nicolau (et al.)
- Institutional Preconditions for Small Animal Imaging
Pages 91-99

Tolba, René H.
- Statistical Considerations for Animal Imaging Studies
Pages 101-116

Ulbrich, Hannes-Friedrich
- Anesthesia and Analgesia in Laboratory Animals
Pages 117-126

Hein, Marc (et al.)
- Drug Administration
Pages 127-152

Hauff, PD Dr. Peter (et al.)
- How to Choose the Right Imaging Modality
Pages 155-161

Kiessling, Fabian (et al.)
- How to Identify Suitable Molecular Imaging Biomarkers
Pages 163-176

Koglin, Norman (et al.)
- Concepts in Diagnostic Probe Design
Pages 177-200

Jacobs, Igor (et al.) X-Ray and X-Ray-CT

Pages 201-225

Brauweiler, Robert (et al.)
- MRI
Pages 227-324

Schroeter, Aileen (et al.)
- Ultrasound
Pages 325-360

Foster, Stuart (et al.)
- PET and SPECT
Pages 361-402

Decristoforo, Clemens (et al.) Optical Imaging

Pages 403-490

Alves, Frauke (et al.)
- Multimodal Imaging and Image Fusion
Pages 491-507

Wehrl, Hans F. (et al.)
- In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting
Pages 511-525

Stout, David (et al.) Qualitative and Quantitative Data Analysis

Pages 529-545

Gremse, Felix
- Guidelines for Nuclear Image Analysis
Pages 547-557

Judenhofer, Martin S. (et al.)
- Kinetic Modeling
Pages 559-580

Hoff, J.
- Data Management in Small Animal Imaging: Conceptual and Technical Considerations
Pages 581-590

Maus, J. (et al.)
- Cell Tracking and Transplant Imaging
Pages 593-603

Rose, Laura C. (et al.)
- Beta Cell Imaging as Part of “Imaging on Metabolic Diseases”
Pages 605-625

Brom, M. (et al.)
- In Vivo Preclinical Imaging of Developmental Biology
Pages 627-650

Vandoorne, Katrien (et al.)
- Imaging in Gynecology Research
Pages 651-662

Laschke, Matthias W., PhD (et al.) Imaging in Cardiovascular Research

Pages 663-688

Schäfers, Michael (et al.)
- Imaging in Neurooncology
Pages 689-725

Waerzeggers, Yannic (et al.)
- Imaging in Neurology Research II: Exploring Plasticity and Cognitive Networks by In Vivo MRI
Pages 727-760

Hamaide, J. (et al.)
- Imaging in Neurology Research III: Neurodegenerative Diseases
Pages 761-772

Endepols, Heike (et al.)
- When Photons Meet Protons: Optogenetics, Calcium Signal Detection, and fMRI in Small Animals
Pages 773-791

Yu, Xin
- Imaging in Oncology Research
Pages 793-819

Weber, Wolfgang A. (et al.)
- PET Imaging in Immunology
Pages 821-844

McCracken, Melissa N. (et al.)
- Molecular Imaging of Infectious Diseases
Pages 845-856

Rolle, Anna-Maria (et al.)
Dr. Fabian Kiessling

Since 2008 Professor is leading the Institute for Experimental Molecular Imaging at the Helmholtz Center of Applied Engineering of the RWTH-University in Aachen. Aim of his research is the development of novel diagnostic probes and imaging tools for a disease specific diagnosis and therapy monitoring. In this context, the main focus is on the investigation of angiogenesis related processes. Fabian Kiessling studied Medicine and graduated at the University of Heidelberg. Until the end of 2002, he worked as resident in the Department of Radiology at the German Cancer Research Center (DKFZ) in Heidelberg. In 2003 he changed to the Department of Medical Physics in Radiology of the DKFZ as leader of the Molecular Imaging group. In parallel he did his clinical training at different Departments of the University of Heidelberg and received the board certification as clinical Radiologist in 2007. Fabian Kiessling habilitated in experimental radiology in 2006. He is author of more than 240 publications and book chapters, received several research awards, among those the „Emil Salzer Price for Cancer Research” and the “Richtzenhain Price”. Shortly after his change to the RWTH-Aachen University he founded the invivoContrast GmbH together with Professor Matthias Bräutigam, which is distributing diagnostic probes for the preclinical market.